Comparing Efficacy and Safety of Dual Antiplatelet Therapy versus Intravenous Thrombolytics in Acute Minor Ischemic Stroke: A Systematic Review and Meta-Analysis

Muhammad Hassan Waseem, Zain ul Abideen, Faizan Shahzad, Momina Riaz Siddiqui, Muhammad Osama, Aizaz Ali, Taimoon Rasheed, Muhammad Wajih Ansari, Rowaid Ahmad, Zara Fahim, Pawan Kumar Thada, Adam A. Dmytriw, Allama Iqbal Medical College, King Edward Medical University, Rawalpindi Medical University, Hayatabad Medical Complex, Khyber Medical College, University of Texas Medical Branch, Sotang Primary Hospital, Neuroendovascular Program, Massachusetts General Hospital , Brigham and Women, s Hospital, Harvard Medical School, Neuroanalytics Collaboration , School of Medicine, Toronto Metropolitan University, Medical Sciences Division, Nuffield Department of Surgical Sciences, University of Oxford

Clinical and Applied Thrombosis/Hemostasis

Published online on May 12, 2026

Abstract

Clinical and Applied Thrombosis/Hemostasis, Volume 32, January-December 2026.
BackgroundAcute minor ischemic stroke (AMIS) frequently results in significant disability despite current treatment options. This meta-analysis evaluated the effectiveness and safety of dual antiplatelet therapy (DAPT) compared to intravenous ...