Injection-Site Sarcomas in Rodent Carcinogenicity Studies: Human Relevance and Labeling Implications
Published online on May 12, 2026
Abstract
Toxicologic Pathology, Ahead of Print.
The two-year rodent carcinogenicity bioassay, often using the subcutaneous (SC) route for parenterally administered drugs, is a regulatory standard for evaluating carcinogenic potential. However, repeated SC injections of nongenotoxic agents or ...
The two-year rodent carcinogenicity bioassay, often using the subcutaneous (SC) route for parenterally administered drugs, is a regulatory standard for evaluating carcinogenic potential. However, repeated SC injections of nongenotoxic agents or ...