Topical Application of Sepia Ink Extract-Loaded Phytosome on Mouse Skin Injury Accelerates Wound Healing: A Histopathological, Immunohistochemical, and Biochemical Study

Islam Ahmed Abdelmawgood, Fatma Alshakmak, Hader I. Sakr, Tarek Atia, Ayman Saber Mohamed, Ahmed W. El-Basyouni, Mazen Ashraf Abdelaziz, Ahmed M. Rochdi, Shady H. Mahmoud, Martin M. Mikhail, Verina S. Shehata, Monica M. Rezkalla, Nada M. Ali, Mariam A. Alsayed, Hajar A. Mutawalli, Jakleen Z. Abujamai, Adel Alghamdi, Wafaa M.A. Abdulrahman, Neamat Mahmoud Abd Elgilil

The International Journal of Lower Extremity Wounds

Published online on May 15, 2026

Abstract

The International Journal of Lower Extremity Wounds, Ahead of Print.
Sepia officinalis ink contains bioactive secondary metabolites abundant in melanin granules, has extensive medicinal properties and is commonly utilized in the prevention of different diseases. This research examined the topical wound healing efficacy of ...