["Psycho-Oncology, Volume 35, Issue 5, May 2026. ", "\nABSTRACT\n\nBackground\nThe COVID‐19 pandemic severely disrupted healthcare and socioeconomic systems linked to worse health outcomes. However, its association with health‐related quality of life (HRQoL) among cancer survivors remains less well defined.\n\n\nAim\nTo evaluate pandemic‐related changes in HRQoL among cancer survivors.\n\n\nMethods\nCancer survivors aged ≥ 18 years were identified in the 2017–2024 Behavioral Risk Factor Surveillance System (BRFSS). Periods were categorized as pre‐pandemic (2017–2019), pandemic (2020–2021), and post‐pandemic (2022–2024). Outcomes included poor physical health (PPH) and poor mental health (PMH; ≥ 14 days/month). Multivariable Poisson regression generated adjusted incidence rate ratios (aIRRs). Interrupted time series analyses (ITSA) assessed level and slope changes.\n\n\nResults\nAmong 194,144 cancer survivors, 35.6% (n = 69,174) were surveyed pre‐pandemic, 20.6% (n = 40,040) during the pandemic, and 43.7% (n = 84,930) post‐pandemic. Most were female (63.1%) and White (79.0%). Compared with pre‐pandemic, the pandemic period was associated with lower adjusted rates of PPH (aIRR 0.91, 95% CI 0.88–0.95) but higher adjusted rates of PMH (aIRR 1.14, 95% CI 1.09–1.20; both p < 0.001). ITSA demonstrated an immediate 14.63% decline in PPH at pandemic onset (95% CI −22.08 to −7.18), whereas PMH demonstrated a pandemic‐era upward trend (7.72%/year, 95% CI 3.05–12.40).\n\n\nConclusion\nAmong cancer survivors, COVID‐19 pandemic was associated with an immediate decrease in the prevalence of poor physical health, followed by a steady increase in the prevalence of poor mental health during the pandemic. Routine mental health screening and scalable psychosocial support are encouraged within survivorship care, particularly during periods of system‐wide disruption.\n\n"]