Explore the Causal Effect of SGLT2 Inhibition on Venous Thromboembolism Events: A Drug-Target Mendelian Randomization Study With Pharmacovigilance Analysis

Jing Liu, Zipei Ma, Piaoran Liu, Tiezhu Yao, Jing He, Tenghui Wang, Mengjia Li, Sihan Liu, Jingtao Ma, Zhenli Li, Department of Cardiology, the Fourth Hospital of Hebei Medical University, s Republic of China, Graduate School, Hebei Medical University, s Republic of China, Department of Cardiology, Anzhen Hospital Affiliated to Capital Medical University, s Republic of China, Department of Immuno-Oncology, The Fourth Hospital of Hebei Medical University, s Republic of China

Clinical and Applied Thrombosis/Hemostasis

Published online on May 28, 2026

Abstract

Clinical and Applied Thrombosis/Hemostasis, Volume 32, January-December 2026.
BackgroundSodium-glucose cotransporter 2 (SGLT2) inhibitors are widely used antidiabetic agents with established cardiorenal benefits, yet their genetic causal association with venous thromboembolism (VTE) remains uncertain.MethodsWe employed a ...