A precautionary tale of lenacapavir drug-drug interactions: A case series of two persons living with HIV receiving long-acting injections

Patricia Pecora Fulco, Elizabeth Winthrop, Gonzalo M. Bearman, Department of Pharmacy, Department of Internal Medicine, Division of Infectious Diseases, Virginia Commonwealth University Health, Department of Internal Medicine, Division of Infectious Diseases, Virginia Commonwealth University Health, Department of Quality , Virginia Commonwealth University Health

International Journal of STD & AIDS: Clinical practice in sexual health

Published online on June 18, 2026

Abstract

International Journal of STD & AIDS, Ahead of Print.
Lenacapavir is now approved for highly treatment experienced persons living with HIV (PLWH) and for HIV pre-exposure prophylaxis (PrEP). Limited lenacapavir clinical data exist with real-world drug-drug interactions. We report two possible drug-drug ...