Natural melanin nanoparticles modified with glycol chitosan for enhanced delivery of oxaliplatin

Güleycan Dedecengiz Varol, Miray Karamese, Seyma Uzum, Kaan Bayer, Rabia Selcen Kuru, Merve Güdül Bacanlı, Sevde Altuntas, Sakip Önder, Gizem Kaleli-Can, Department of Biomedical Engineering, Yildiz Technical University, Department of Tissue Engineering, Institution of Health Sciences, University of Health Sciences Turkey, Experimental Medicine Research and Application Center, Validebag Research Park, University of Health Sciences Turkey, Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Uskudar University, Department of Pharmaceutical Toxicology, Gülhane Faculty of Pharmacy, University of Health Sciences Turkey, Department of Biomedical Engineering, İzmir Democracy University

Journal of Biomaterials Applications

Published online on June 19, 2026

Abstract

Journal of Biomaterials Applications, Ahead of Print.
The aim of this study was to investigate the potential of natural melanin nanoparticles (MNPs) as carriers for oxaliplatin (OXP) delivery, with glycol chitosan (GC) surface modification to improve dispersion behavior and drug interaction. The isolated ...