An evaluation of designs for Phase I/IIa dose-finding studies in Tuberculosis
Statistical Methods in Medical Research: An International Review Journal
Published online on June 01, 2026
Abstract
Statistical Methods in Medical Research, Volume 35, Issue 7, Page 1349-1365, July 2026.
Early development of tuberculosis (TB) treatments often separates dose-finding in healthy volunteers (Phase I) and safety and early activity in patients (Phase IIa). The BTZ-043 study (NCT04044001) is a recent study that combined these two objectives in ...
Early development of tuberculosis (TB) treatments often separates dose-finding in healthy volunteers (Phase I) and safety and early activity in patients (Phase IIa). The BTZ-043 study (NCT04044001) is a recent study that combined these two objectives in ...