Lineage infidelity in FH-deficient RCC with secondary somatic alterations: a case report and implications for diagnosis and treatment

Jianping Zhao, Derek B. Allison, Giannicola Genovese, Stephanie Rock, Noah Spies, Michael Hensley, Gleb Khegai, Anastasiya Makeeva, Daria Melikhova, Lev Bedniagin, Patrick J. Hensley, Zin W. Myint, Pavlos Msaouel

Therapeutic Advances in Medical Oncology

Published online on June 17, 2026

Abstract

Therapeutic Advances in Medical Oncology, Volume 18, January-December 2026.
Fumarate hydratase (FH)-deficient renal cell carcinoma (RCC) can exhibit striking histologic and immunophenotypic heterogeneity. A 36-year-old woman with uterine leiomyomas presented with a 5.1-cm left renal sinus mass and retroperitoneal adenopathy. ...