Development and validation of a clinical scoring system for the prediction of methotrexate treatment response in rheumatoid arthritis patients: a multicenter real-world study

Rudy Hidayat, Fara Fauzia, Suryo Anggoro Kusumo Wibowo, Anna Ariane, Radiyati Umi Partan, Putri Muthia, Ika Vemilia Warlisti, Bantar Suntoko, Mirza Zaka Pratama, Cesarius Singgih Wahono, Lita Diah Rahmawati, Pande Ketut Kurniari, Anggarda Kristianti Utomo, Najirman Najirman, Eka Kurniawan, Yulyani Werdiningsih, Faridin Pango, Mochammad Alfansyah Dhifanra, Jessica Audrey, Faisal Parlindungan

Therapeutic Advances in Musculoskeletal Disease

Published online on June 10, 2026

Abstract

Therapeutic Advances in Musculoskeletal Disease, Volume 18, January-December 2026.
Background:Methotrexate (MTX) remains the anchor drug in rheumatoid arthritis (RA) management. However, treatment response varies widely.Objectives:This study aimed to develop and validate a simple scoring model for predicting MTX monotherapy treatment ...