Dibromoacetonitrile mediated depression-like behavior in mice and induced HT22 cytotoxicity through the MKP-1/P38 MAPK signaling pathway and the antagonistic effect of N-acetylcysteine

Cong Qi, Xinwei Xu, Lan Zhang, Jiahui Gao, Guosheng Shan, Guangqiao Liang, Yang Ye, Fang Li, Department of Pharmacy, Jurong Hospital Affiliated to Jiangsu University, School of Medicine, Jiangsu University

Toxicology and Industrial Health

Published online on May 26, 2026

Abstract

Toxicology and Industrial Health, Volume 42, Issue 8, Page 284-302, August 2026.
Environmental pollutants are an important cause of depression. Dibromoacetonitrile (DBAN) is a disinfection by-product, which is neurotoxic and induces oxidative stress. This study aimed to elucidate whether and how DBAN provoked depression-like behavior. ...