["American Journal of Human Biology, Volume 38, Issue 7, July 2026. ", "\nABSTRACT\n\nIntroduction\nThe second‐to‐fourth digit ratio (2D:4D) has been extensively investigated as a potential biomarker of prenatal sex hormone exposure across biological, psychological, and behavioral sciences. Despite rapid growth in this field, a comprehensive evaluation of its developmental course and conceptual framework has been limited.\n\n\nMethods\nThis study provides a comprehensive bibliometric analysis of global 2D:4D research from 1998 to 2025. Bibliometrix (R software) and VOSviewer were employed to evaluate publication trends, influential authors, countries, institutions, journals, collaboration networks, keyword co‐occurrence, and co‐citation structures.\n\n\nResults\nA total of 1692 articles and reviews were included. The results reveal a steady growth in publications, with an average annual increase of 17.51%, alongside expanding international collaboration. Early studies focused on sexual dimorphism, prenatal androgen exposure, and developmental biology, whereas recent research emphasizes psychological traits, stress‐related outcomes, and health associations. Keyword and co‐citation analyses identified multiple thematic clusters, highlighting the interdisciplinary evolving nature of the field.\n\n\nConclusion\nOverall, this study demonstrates the historical evolution, current landscape, and emerging trends of 2D:4D research. The findings underscore the need for greater methodological standardization, increased use of longitudinal and cross‐cultural designs, and closer integration of biological and translational models to advance future research.\n\n"]