Development and Validation of an Early Risk Prediction Model for Sepsis-Induced Coagulopathy Based on Machine Learning

Qiuxiang Yang, Liu Fang, Caiyi Ren, Wanjuan Xiong, Jili Zou, Luyu Yang, Qingyuan Zeng, Department of Pharmacy, Wuhan Third Hospital , Tongren Hospital of Wuhan University, Faculty of Medicine, Wuhan University of Science and Technology, School of Pharmacy, Hubei University of Medicine, Department of Critical Care Medicine, Wuhan Third Hospital , Tongren Hospital of Wuhan University

Clinical and Applied Thrombosis/Hemostasis

Published online on July 20, 2026

Abstract

Clinical and Applied Thrombosis/Hemostasis, Volume 32, January-December 2026.
ObjectiveTo develop and validate machine learning models for early prediction of sepsis-induced coagulation dysfunction (SIC) risk at intensive care unit (ICU) admission, before diagnostic criteria are fully met.MethodsThis retrospective cohort study ...