Association Between TNF-Alpha Levels and Atrial Fibrillation Outcomes: A Systematic Review and Meta-Analysis

Alireza Fatemi, Bahar Amirgholami, Yasmin Yazdooei, Aylin Taghipour, Amirali Zamani, Ali Ajdarkosh, Department of Surgery, Surgery Research Center, School of Medicine, Rasool-E Akram Hospital, Iran University of Medical Sciences, Department of Cardiology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Cardiovascular Surgery Research and Development Committee, Iran University of Medical Sciences

Clinical and Applied Thrombosis/Hemostasis

Published online on June 26, 2026

Abstract

Clinical and Applied Thrombosis/Hemostasis, Volume 32, January-December 2026.
Background and objectivesPrevious studies suggest a link between tumor necrosis factor-alpha (TNF-alpha) levels and atrial fibrillation (AF). However, the nature of this relationship is disputed. To address this, we conducted a study to gather and assess ...