Gelatin-based cryogels seeded with exosomes enhance osteogenic activity and bone regeneration in a rabbit femoral defect model

Joseph Yang, Daniel Yang, Jhe-Lun Hu, Yong-Ji Chen, Shwu-Jen Chang, Shan-Wei Yang, Laboratory of Regenerative Medicine and Biosensors, I-Shou University, Kaohsiung City, Cambridge International Programme, St Dominic Catholic High School, Kaohsiung City, Department of Biomedical Engineering, I-Shou University, Kaohsiung City, Department of Orthopedics, Kaohsiung Veterans General Hospital, Kaohsiung City, School of Nursing, Fooyin University, Kaohsiung City, Department of Leisure and Sports Management, Cheng Shiu University, Kaohsiung City

Journal of Biomaterials Applications

Published online on June 24, 2026

Abstract

Journal of Biomaterials Applications, Ahead of Print.
The development of biomaterial scaffolds that combine structural support with biological activation remains critical for bone defect repair. In this study, gelatin-based cryogels (GBCs) that incorporate β-tricalcium phosphate (β-TCP) and hyaluronic acid (...