Experimental study on the repair of rabbit femoral condyle critical-sized bone defect using polyphosphoester-amino acid copolymer-composite nanohydroxyapatite filling material

Mingzhong Xiao, Hua Gao, Hui Dong, Yan Xiong, Zeping Yu, Wenli Zhang, Hong Duan, Department of Orthopedic Surgery, Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Changzhou Wujin Hospital of Traditional Chinese Medicine, Department of Orthopaedics, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China

Journal of Biomaterials Applications

Published online on July 07, 2026

Abstract

Journal of Biomaterials Applications, Ahead of Print.
To engineer a porous nanohydroxyapatite/polyphosphoester-amino acid composite bone graft substitute (nHA/PPE-AA) in granular form and evaluate its reparative efficacy and in vivo safety in a rabbit femoral condyle critical-sized defect (CSD) model. Porous ...