Aripiprazole and Unexpected Salivation: A Case of Drug-Induced Sialorrhea Refractory to Anticholinergics

Charlie Yang, Keren Eagers, Desiree Kosmisky, Kristen Nagy, Pharmacy Department, Wingate University School of Pharmacy, Pharmacy Department, Atrium Health Pineville, Pharmacy Department, Atrium Health Cabarrus, Pharmacy Department, Atrium Health Behavioral Health-Charlotte, Pharmacy Department, Sandra and Leon Levine Psychiatry Residency Program, Pharmacy Department, Mercer University Savannah, Gateway Behavioral Health Services

Journal of Pharmacy Practice

Published online on June 29, 2026

Abstract

Journal of Pharmacy Practice, Ahead of Print.
Sialorrhea, or excessive drooling, is a distressing side effect of certain antipsychotic medications, including aripiprazole, clozapine, and olanzapine. We present the case of a 53-year-old female with bipolar I disorder who presented with altered mental ...