External validation of the population pharmacokinetic model of meropenem in patients undergoing neonatal extracorporeal membrane oxygenation and continuous renal replacement therapy

Pavla Pokorná, Danica Michaličková, Jan Bělohlávek, Jonas Berner, Department of Pediatrics and Inherited Metabolic Disorders, General University Hospital, and First Faculty of Medicine, Charles University, Czech Republic, Department of Physiology and Pharmacology, Karolinska Institutet, Department of Pediatric Surgery, Erasmus Medical Centre Sophia Children, s Hospital, The Netherlands, ECMO Centre, Department of Pediatric Perioperative Medicine and Intensive Care, Astrid Lindgren Children, s Hospital, Karolinska University Hospital, Institute of Pharmacology, General University Hospital, and First Faculty of Medicine, Charles University, Czech Republic, nd Department of Medicine, Department of Cardiovascular Medicine, First Faculty of Medicine Charles University and General University Hospital, Czech Republic

Perfusion

Published online on June 23, 2026

Abstract

Perfusion, Ahead of Print.
IntroductionThere is a lack of data supporting rationale drug use with extracorporeal membrane oxygenation (ECMO). The aim of this study was to externally validate a previously developed population pharmacokinetic model of meropenem in neonatal ECMO and ...