Bevacizumab plus iparomlimab/tuvonralimab with hepatic artery infusion chemotherapy followed by stereotactic body radiotherapy in patients with BCLC stage C hepatocellular carcinoma with thrombus and/or extrahepatic oligometastases (BITS-TO-HCC): study protocol of a prospective, single-center, single-arm, phase II study

Yuxin Liu, Haohua Wang, Kunli Zhu, Shumei Jiang, Fang Shi, Rui Feng, Xue Dou, Lei Xu, Zhe Gong, Shuai Wang, Chen Wang, Po Wang, Xiang Zhang, Jinbo Yue

Therapeutic Advances in Medical Oncology

Published online on July 24, 2026

Abstract

Therapeutic Advances in Medical Oncology, Volume 18, January-December 2026.
Background:First-line immunotherapy-based combinations have improved outcomes in advanced hepatocellular carcinoma (HCC), but many patients with Barcelona Clinic Liver Cancer (BCLC) stage C HCC with portal vein tumor thrombus (PVTT) and/or extrahepatic ...