Impact of postoperative chemotherapy in patients resected for esophagogastric adenocarcinoma with major pathological response after preoperative chemotherapy: a study from the FREGAT database

Laure Corazzin, Elodie Jeanbert, Olivier Glehen, Caroline Gronnier, Laurent Sulpice, Jean-Marc Gornet, Brice Paquette, Jean-Marc Regimbeau, Cécile Brigand, Xavier-Benoît D, Pierre-Yves Brichon, Johan Gagnaire, Thibault Voron, Muriel Mathonnet, Christophe Penna, Nicolas Regenet, Côme Lepage, Nicolas Carrere, Ugo Marchese, Leonor Benhaim, Jean-Michel Fabre, Frédéric Di Fiore, Frédéric Borie, Pierre Emmanuel Bonnot, Olivier Bouché, David Tougeron, Antoine Adenis, Guillaume Piessen, Marie Muller

Therapeutic Advances in Medical Oncology

Published online on July 15, 2026

Abstract

Therapeutic Advances in Medical Oncology, Volume 18, January-December 2026.
Background:In locally advanced esophagogastric adenocarcinoma (EGA), perioperative chemotherapy is the standard of care and can result in complete/major pathological response. In this setting, real-world data on the impact of postoperative chemotherapy ...