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Ketamine alters the aperiodic EEG exponent in major depression: implications for cortical E/I balance and treatment prediction

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Therapeutic Advances in Psychopharmacology

Published online on

Abstract

Therapeutic Advances in Psychopharmacology, Volume 16, January-December 2026.
Background:Ketamine has emerged as a promising rapid-acting antidepressant for treatment-resistant depression (TRD), yet its mechanisms of action and reliable biomarkers of treatment response remain poorly understood. Recent evidence suggests that the ...