High-titer antinuclear antibodies are associated with severe immune-related toxicity and exploratory survival outcomes in advanced gastric cancer immunotherapy

Wanrong Liu, Hui Tang, Ningning Li, Wei Qiu, Xiaoyuan Li, Lin Zhao, Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences , Peking Union Medical College, Peking Union Medical College, Chinese Academy of Medical Sciences, Department of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences , Peking Union Medical College

Therapeutic Advances in Medical Oncology

Published online on August 06, 2026

Abstract

Therapeutic Advances in Medical Oncology, Volume 18, January-December 2026.
BackgroundClinicians often screen for autoantibodies before initiating immune checkpoint inhibitors (ICIs) in advanced gastric cancer (GC), yet the utility of organ-specific panels remains unclear.ObjectivesTo evaluate the association of baseline ...