Efficacy and Safety of Sequential Nephron Blockade Compared to Standard Loop Diuretic for Fluid De-resuscitation in the ICU

Noelle Brittain, Megan Van Berkel Patel, Lauren Caldwell, Andrew Shine, Jeremy Greenberg, Jessica Parker, Nolan Rossman, Jessica Briscoe, Department of Clinical Pharmacy, Department of Emergency Medicine, University of Tennessee College of Medicine, Department of Critical Care, Office of Research and Education, Corewell Health West, Grand Rapids

Journal of Pharmacy Practice

Published online on August 17, 2026

Abstract

Journal of Pharmacy Practice, Ahead of Print.
Diuretics are integral in fluid de-resuscitation of ICU patients following initial stabilization. While loop diuretics are commonly used, sequential nephron blockade (SNB) is an alternative diuretic strategy that combines a loop diuretic with at least one ...