As the incidence rate of lifestyle-related chronic conditions such as cardiovascular disease, obesity, and type 2 diabetes continues to increase, the importance of regular exercise and a healthy diet for improving or maintaining good health is critical. Exercise training is known to improve fitness and many health risk factors, as well as to improve the performance of competitive athletes. It has become increasingly clear, however, that nutrient intake before, during, and after exercise sessions has a powerful influence on the adaptive response to the exercise stimuli. In this review, the science behind nutrient timing will be discussed as it relates to exercise performance, recovery, and training adaptation. Evidence will be provided that validates intake of appropriate nutrients before, during, and immediately after exercise not only to improve exercise performance but also to maximize the training response. Ultimately, the combined response to exercise and proper nutrient intake leads to not only better performance in athletes but also greater health benefits for all exercisers.