Human papillomavirus is the cause of cervical and anal cancer. Human immunodeficiency virus infection and cocaine use are associated with increased risk for human papillomavirus infection and associated diseases, but little is known about HIV-infected drug users' awareness of human papillomavirus. We investigate human papillomavirus awareness among HIV-infected, sexually active crack cocaine users from two inner-city hospitals in Florida and Georgia during their inpatient stays. Multivariate logistic regression analysis was used to examine potential correlates of human papillomavirus awareness. We interviewed 215 participants (110 women; 105 men) about their awareness of human papillomavirus infection. Overall, only 25% of respondents reported having heard of human papillomavirus. The odds of having heard of human papillomavirus were greater for respondents having a high-school degree or higher, having ever gone to an HIV provider for HIV care, and having two or more sexual partners. Despite increased susceptibility to human papillomavirus infection and human papillomavirus-related cancers, our study findings suggest that sexually active HIV-infected crack cocaine users have little awareness of human papillomavirus and highlight the need for programs targeting human papillomavirus education for HIV-infected crack cocaine drug users.