The Hyaline Vascular Type of Castleman's Disease of the Ovary: A Case Report
International Journal of Surgical Pathology
Published online on January 21, 2014
Abstract
Castleman’s disease in the pelvic cavity is rare. We present a 72-year-old woman with hyaline vascular type of Castleman’s disease of the right ovary. Right ovarian enlargement was detected in the medical examination. Computed tomography revealed a solid mass, measured 2.5 cm in size, in the right ovary. A bilateral salpingo-oophorectomy was performed. Morphologically, lymphoid follicles with regressed germinal centers (GCs) were surrounded by a broad mantle zone composed of concentric rings of small lymphocytes, and the hyalinized blood vessels with plump endothelial cells penetrated radially into GCs. Proliferation of follicular dendritic cells, which were positive for CD21 and epidermal growth factor receptor, were detected in GCs and mantle zone. No other lesions were found. To the best of our knowledge, this is the first case of hyaline vascular type of Castleman’s disease of ovarian primary.