Concussion has become a prevalent injury in the sport of American football, and its severity can be influenced by the mass of the impactor, velocity, compliance, and direction of impact. As a result, it is important to characterize how American football helmets perform against these impact characteristics. The purpose of this research is to examine how an American football helmet performs across velocities and impact angles which can occur in the sport of American football. The methods used a combination of Hybrid III headform impacts combined with a finite element modeling approach to find the brain deformation variables known to be associated with concussion. At the 9.5 m/s impacts, the brain deformation metrics showed an increase in risk of concussion. Also, the region of the brain with the largest magnitude deformation shifted with differing velocities when analyzed using maximum principal strain but not von Mises stress. The results indicate that impact conditions (location and velocity) can influence the regional brain strains.