The current study assessed the extent to which parental validating and invalidating behaviors (a) could be reliably measured in parent–adolescent relationships, (b) differed significantly between clinic and nonclinic families, and (c) were associated with measures of adolescent emotion dysregulation, behavior problems, and parent–adolescent relationship satisfaction. Adolescents (N = 29; age range = 12–18; 62% female) and their parents completed a variety of self-report and parent-report measures of adolescent functioning. Ratings of parents’ validating and invalidating responses during video-recorded social support and problem-solving interactions were obtained. Results indicated that parental validating and invalidating behaviors (a) were measured with a high degree of reliability, (b) differed significantly between clinic and nonclinic families, and (c) were correlated, in expected directions, with adolescent emotion dysregulation, externalizing problem behaviors, and adolescent relationship satisfaction. The implications of these findings are discussed in terms of both research and potentially improved family interventions.