Mind-sets are beliefs regarding the malleability of self-attributes. Research suggests they are domain-specific, meaning that individuals can hold a fixed (immutability) mind-set about one attribute and a growth (malleability) mind-set about another. Although mind-set specificity has been investigated for broad attributes such as personality and intelligence, less is known about mental health mind-sets (e.g., beliefs about anxiety) that have greater relevance to clinical science. In two studies, we took a latent variable approach to examine how different mind-sets (anxiety, social anxiety, depression, drinking tendencies, emotions, intelligence, and personality mind-sets) were related to one another and to psychological symptoms. Results provide evidence for both domain specificity (e.g., depression mind-set predicted depression symptoms) and generality (i.e., the anxiety mind-set and the general mind-set factor predicted most symptoms). These findings may help refine measurement of mental health mind-sets and suggest that beliefs about anxiety and beliefs about changeability in general are related to clinically relevant variables.