HIV/AIDS is a perennial health issue in South Africa; the disease was the major cause of the 200,000 deaths in South Africa in 2013. The menace has increased with the increase in the number of people living with HIV/AIDS in South Africa, despite the rigorous preventive strategies that were adopted in the country. This article explores localism in communication as a tool of health development in promoting HIV/AIDS awareness and knowledge in Africa, with a particular reference to South Africa. This article draws attention to the various localized channels of communicating development messages in relation to their significance in facilitating HIV/AIDS awareness and knowledge.