The most common failure modes for guideway are wear and contact fatigue, which are significantly influenced by the friction properties of the contact surfaces. In this paper, three-dimensional surface parameters of surface roughness are investigated to evaluate guideway surface. First, an effective three-dimensional surface model is achieved using wavelet transform method and a reverse engineering software (Geomagic Studio). Secondly, effects of the functional surface parameters on friction force, mean pressure, and friction coefficient are studied using the computational fluid dynamics simulation method, and a regression model to predict friction force is achieved. Thirdly, the optimal surface parameters combinations are analyzed looking at friction property index, and the simulation results are compared. Finally, a verification test is conducted to detect the validity of the simulation research. The results show a good agreement between the experimental results and simulations. This study provides theoretical guidance for the manufacture of guideway.